References

Nigella Sativa. (Black Seed oil and Thymoquinone)

Allergies

Herbal treatment of allergic rhinitis: the use of Nigella sativa https://www.sciencedirect.com/science/article/abs/pii/S0196070910001407
Nigella sativa (black seed) oil does not affect the T-helper 1 and T-helper 2 type cytokine production from splenic mononuclear cells in allergen sensitized mice https://www.sciencedirect.com/science/article/abs/pii/S037887410500214X
Clinical and experimental effects of Nigella sativa and its constituents on respiratory and allergic disorders https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526035/

Anemia

Nigella sativa improves anemia, enhances immunity and relieves iron overload-induced oxidative stress as a novel promising treatment in children having beta-thalassemia major https://www.sciencedirect.com/science/article/abs/pii/S2210803318300563
Effect of black seed oil supplementation on selected immunological, hematological and Iron status parameters in ribavirin treated female albino rats https://pubmed.ncbi.nlm.nih.gov/29716855/
Immunomodulatory effect of Nigella sativa oil treatment in iron deficiency anemia caused by refractory coeliac disease https://www.researchgate.net/publication/286603310_Immunomodulatory_effect_of_Nigella_sativa_oil_treatment_in_iron_deficiency_anemia_caused_by_refractory_coeliac_disease

Anti-biotic

Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387228/
Structural Characterization, Antimicrobial Activity, and In Vitro Cytotoxicity Effect of Black Seed Oil https://www.hindawi.com/journals/ecam/2019/6515671/
Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses https://www.hindawi.com/journals/ecam/2019/1528635/#conclusion-and-future-prospects
GC–MS characterisation and antibacterial activity evaluation of Nigella sativa oil against tderse strains of Salmonella https://www.tandfonline.com/doi/abs/10.1080/14786419.2014.947493

Anti-inflammatory

Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884216/
Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes https://www.mdpi.com/2076-3921/8/2/51
An Investigation of the Analgesic and Anti-Inflammatory Effects of Nigella sativa Seed Polyphenols https://www.liebertpub.com/doi/abs/10.1089/jmf.2005.8.488
The Anti-Inflammatory Activity of Nigella sativa Balm Sticks https://www.mdpi.com/2218-0532/87/1/3/htm

Anti-oxidant

Effect of Nigella sativa on Glucose Concentration, Lipid Peroxidation, Anti-Oxidant Defence System and Liver Damage in Experimentally-Induced Diabetic Rabbits https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1439-0442.2001.00393.x
A New Oleanane Type Saponin from the Aerial Parts of Nigella sativa with Anti-Oxidant and Anti-Diabetic Potential https://www.mdpi.com/1420-3049/25/9/2171
Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406245/
Antimicrobial, anti-inflammatory and antioxidant activity of Nigella sativa in clinically endometritic cows https://www.tandfonline.com/doi/full/10.1080/09712119.2015.1091341
Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy https://www.mdpi.com/2076-3921/9/12/1260

Antiviral

Protective and antiviral activities of Nigella sativa against avian influenza (H9N2) in turkeys https://core.ac.uk/download/pdf/82577428.pdf
Prophetic Medicine-Nigella Sativa (Black cumin seeds) – Potential herb for COVID-19? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338708/
Thymoquinone: A Promising Natural Compound with Potential Benefits for COVID-19 Prevention and Cure https://www.dovepress.com/thymoquinone-a-promising-natural-compound-with-potential-benefits-for--peer-reviewed-fulltext-article-DDDT
The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family https://link.springer.com/article/10.1007/s11033-014-3019-7

Asthma

Nigella sativa as an anti-inflammatory agent in asthma https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3858-8
Comparative Immunomodulatory Activity of Nigella sativa L. Preparations on Proinflammatory Mediators: A Focus on Asthma https://www.frontiersin.org/articles/10.3389/fphar.2018.01075/full
The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients The possible prophylactic effect of Nigella sativa seed extract in asthmatic patientshttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1472-8206.2007.00509.x

Cancer Research

Anticancer Activities of Nigella Sativa (Black Cumin) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252704/
Therapeutic Implications of Black Seed and Its Constituent Thymoquinone in the Prevention of Cancer through Inactivation and Activation of Molecular Pathways https://www.hindawi.com/journals/ecam/2014/724658/
Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive https://www.sciencedirect.com/science/article/pii/S0975947616300389
Anti-tumor properties of blackseed (Nigella sativa L.) extract https://www.scielo.br/j/bjmbr/a/Zs57kV9Lt8J4PB4ZHbLkR8b/?format=pdf&lang=en
Anticancer activity of Nigella sativa (black seed) and its relationship with the thermal processing and quinone composition of the seed https://www.dovepress.com/anticancer-activity-of-nigella-sativa-black-seed-and-its-relationship--peer-reviewed-fulltext-article-DDDT
Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies https://www.frontiersin.org/articles/10.3389/fphar.2017.00295/full
Antiproliferative and apoptotic effects of proteins from black seeds (Nigella sativa) on human breast MCF-7 cancer cell line https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-019-2804-1

Cardiovascular support

Cardiovascular Effects of Nigella Sativa L. and its Constituents https://www.ijpsonline.com/articles/cardiovascular-effects-of-inigella-sativai-l-and-its-constituents-3555.html
Cardiac Inotropic Effect of Long-Term Administration of Oral Thymoquinone https://www.hindawi.com/journals/ecam/2019/8575136/
Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633670/
Effects of two-months Nigella sativa supplementation on cardiac hemodynamics and adrenergic responsiveness https://jpma.org.pk/article-details/1715

Cognition

The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers https://www.sciencedirect.com/science/article/abs/pii/S0378874113003395
Nigella sativa and Thymoquinone attenuate oxidative stress and cognitive impairment following cerebral hypo perfusion in rats https://link.springer.com/article/10.1007/s11011-019-00394-4
The Role of Nigella sativa and Its Active Constituents in Learning and Memory https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789020/
Neuropharmacological effects of Nigella sativa https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884225/

Covid

Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19 https://www.tandfonline.com/doi/full/10.1080/13880209.2021.1931353
Honey and Nigella sativa against COVID-19 in Pakistan (HNS-COVID-PK): A multi-center placebo-controlled randomized clinical trial https://www.medrxiv.org/content/10.1101/2020.10.30.20217364v4.full
Nigella sativa L as a potential phytotherapy for coronavirus disease 2019: A mini review of in silico studies https://www.sciencedirect.com/science/article/pii/S0011393X2030028X

Diabetes

Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/31817324/
How Nigella sativa Seeds Treat Diabetes and Ameliorates Diabetes Complications and Safety Studies: An Over View https://www.researchgate.net/publication/312916160_How_Nigella_sativa_Seeds_Treat_Diabetes_and_Ameliorates_Diabetes_Complications_and_Safety_Studies_An_Over_View
Mechanisms of the hypoglycemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters https://www.sciencedirect.com/science/article/abs/pii/S0034528804000499

Hypertension

Mechanisms of the antihypertensive effects of Nigella sativa oil in L-NAME-induced hypertensive rats https://www.scielo.br/j/clin/a/fbx5ym9MbFzQ3fG84jP8Bbh/?format=html&lang=en
The Black Seed, Nigella sativa (Ranunculaceae), for Prevention and Treatment of Hypertension https://www.researchgate.net/publication/331210582_The_Black_Seed_Nigella_sativa_Ranunculaceae_for_Prevention_and_Treatment_of_Hypertension
Nigella sativa and Its Protective Role in Oxidative Stress and Hypertension https://www.hindawi.com/journals/ecam/2013/120732/

Immune system support

A review on therapeutic potential of Nigella sativa: A miracle herb https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642442/
Nigella sativa: Reduces the Risk of Various Maladies https://www.tandfonline.com/doi/abs/10.1080/10408390902768797
The Effects of Nigella Sativa on the Immune Disorders https://www.authorea.com/doi/full/10.22541/au.158878856.61578558
THE EFFECTS of Nigella sativa OIL ON THE IMMUNE SYSTEM OF RAINBOW TROUT WITH DIFFERENT APPLICATION METHODS THE EFFECTS of Nigella sativa OIL ON THE IMMUNE SYSTEM OF RAINBOW TROUT WITH DIFFERENT APPLICATION METHODS

Joint support

Effect of Topical Application of Nigella Sativa Oil and Oral Acetaminophen on Pain in Elderly with Knee Osteoarthritis: A Crossover Clinical Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358924/
Effect of an orally formulated processed black cumin, from Iranian traditional medicine pharmacopoeia, in relieving symptoms of knee osteoarthritis: A prospective, randomized, double-blind and placebo-controlled clinical trial https://onlinelibrary.wiley.com/doi/abs/10.1111/1756-185X.13066
Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety https://www.mdpi.com/2072-6643/13/6/1784/htm
Investigation of the effect of black cumin oil on pain in osteoarthritis geriatric intdiduals https://pubmed.ncbi.nlm.nih.gov/29705470/
Investigation of the effect of black cumin oil on pain in osteoarthritis geriatric intdiduals https://www.sciencedirect.com/science/article/abs/pii/S1744388117302487

Respiratory Support

Therapeutic effects of black seed oil supplementation on chronic obstructive pulmonary disease patients: A randomized controlled double blind clinical trial https://www.sciencedirect.com/science/article/pii/S2405844020315541
The effects of Nigella sativa on respiratory, allergic and immunologic disorders, evidence from experimental and clinical studies, a comprehensive and updated review https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.7003
The medicinal potential of black seed (Nigella sativa) and its components The medicinal potential of black seed (Nigella sativa) and its components

Rheumatoid Arthritis

Immunomodulatory Effect of Nigella sativa Oil on T Lymphocytes in Patients with Rheumatoid Arthritis https://www.tandfonline.com/doi/abs/10.3109/08820139.2016.1153649
Nigella sativa in controlling Type 2 diabetes, cardiovascular, and rheumatoid arthritis diseases: Molecular aspects https://www.jmsjournal.net/article.asp?issn=1735-1995;year=2021;volume=26;issue=1;spage=20;epage=20;aulast=Hadi
Elucidation of molecular mechanisms underlying the protective effects of Thymoquinone against rheumatoid arthritis https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.22884
Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses https://www.hindawi.com/journals/ecam/2019/1528635/

Weight loss/Obesity

The effect of Nigella sativa on appetite, anthropometric and body composition indices among overweight and obese women: A crossover, double-blind, placebo-controlled, randomized clinical trial https://www.sciencedirect.com/science/article/pii/S0965229920319208
Effects of oral Nigella sativa oil on the expression levels and serum concentrations of adiponectin, PPAR-γ, and TNF-α in overweight and obese women: a study protocol for a crossover-designed, double-blind, placebo-controlled randomized clinical trial https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3568-0
Mitigation of Obesity-Promoted Diseases by Nigella sativa and Thymoquinone https://www.researchgate.net/publication/223959479_Mitigation_of_Obesity-Promoted_Diseases_by_Nigella_sativa_and_Thymoquinone
The effects of Nigella sativa L. on obesity: A systematic review and meta-analysis https://www.researchgate.net/publication/323848576_The_effects_of_Nigella_sativa_L_on_obesity_A_systematic_review_and_meta-analysis

Elderberry (Sambucas nigra)

Anti-bacteria

Elderberry is anti-bacterial, anti-viral and modulates the immune system: anti-bacterial, anti-viral and immunomodulatory non-clinical (in-vitro) effects of elderberry fruit and flowers (Sambucus nigra): a systematic review https://www.researchgate.net/publication/339237008_Elderberry_is_anti-bacterial_anti-viral_and_modulates_the_immune_system_anti-bacterial_anti-viral_and_immunomodulatory_non-clinical_in-vitro_effects_of_elderberry_fruit_and_flowers_Sambucus_nigra_a_sy
ABSTRACT: Elderberry (Sambucus nigra) is anti-bacterial, anti-viral and modulates the immune system https://www.researchgate.net/publication/339236865_ABSTRACT_Elderberry_Sambucus_nigra_is_anti-bacterial_anti-viral_and_modulates_the_immune_system
Bioactive properties of Sambucus nigra L. as a functional ingredient for food and pharmaceutical industry https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185606/
IN SILICO STUDY DEMONSTRATES MULTIPLE BIOACTIVE COMPOUNDS OF Sambucus PLANT PROMOTE DEATH CELL SIGNALING PATHWAY VIA FAS RECEPTOR https://www.researchgate.net/profile/Wira-Putra-2/publication/344477638_IN_SILICO_STUDY_DEMONSTRATES_MULTIPLE_BIOACTIVE_COMPOUNDS_OF_Sambucus_PLANT_PROMOTE_DEATH_CELL_SIGNALING_PATHWAY_VIA_FAS_RECEPTOR/links/

Anti-depressant

Antidepressant activities of Sambucus ebulus and Sambucus nigra https://pubmed.ncbi.nlm.nih.gov/25491608/
Antidepressant activities of Sambucus ebulus and Sambucus nigra https://www.researchgate.net/publication/269415569_Antidepressant_activities_of_Sambucus_ebulus_and_Sambucus_nigra
Beta-Glucan as Wall Material in Encapsulation of Elderberry (Sambucus nigra) Extract https://link.springer.com/article/10.1007/s11130-019-00741-x
Bioactive properties of Sambucus nigra L. as a functional ingredient for food and pharmaceutical industry https://www.sciencedirect.com/science/article/abs/pii/S1756464617306977

Anti-viral

A Review of the Antiviral Properties of Black Elder (Sambucus nigra L.) Products https://pubmed.ncbi.nlm.nih.gov/28198157/
A Review of the Antiviral Properties of Black Elder ( Sambucus nigra L.) Products: Antiviral Properties of Black Elder ( Sambucus nigra L.) https://www.researchgate.net/publication/313763286_A_Review_of_the_Antiviral_Properties_of_Black_Elder_Sambucus_nigra_L_Products_Antiviral_Properties_of_Black_Elder_Sambucus_nigra_L
Antiviral properties of Elderberry https://www.researchgate.net/publication/340236781_Antiviral_properties_of_Elderberry
Antiviral and healing potential of Sambucus nigra extracts https://www.researchgate.net/profile/Joanna-Cymerys/publication/343733298_Antiviral_and_healing_potential_of_Sambucus_nigra_extracts/links/

Cancer

A Comparative Evaluation of the Anticancer Properties of European and American Elderberry Fruits https://www.researchgate.net/publication/6598701_A_Comparative_Evaluation_of_the_Anticancer_Properties_of_European_and_American_Elderberry_Fruits
The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines http://www.alkalinediet.com/pdf/Elderberry/ElderberryAntiViral.pdf
Advanced research on the antioxidant and health benefit of elderberry (Sambucus nigra) in food – a review https://www.sciencedirect.com/science/article/pii/S1756464614002400

Colds and flu

Sambucus nigra (black elder) as alternative treatment for cold and flu https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347422/
Anti-influenza activity of elderberry (Sambucus nigra) https://www.sciencedirect.com/science/article/abs/pii/S1756464619300313
Inhibition of Several Strains of Influenza Virus in Vitro and Reduction of Symptoms by an Elderberry Extract (Sambucus nigra L.) during an Outbreak of Influenza B Panama https://www.liebertpub.com/doi/abs/10.1089/acm.1995.1.361
Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials https://www.sciencedirect.com/science/article/abs/pii/S0965229918310240
Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial https://www.mdpi.com/2072-6643/8/4/182

Covid

The effects of Sambucus nigra berry on acute respiratory viral infections: A rapid review of clinical studies https://www.sciencedirect.com/science/article/abs/pii/S2212958820301543
Myth Busters: Dietary Supplements and COVID-19 https://journals.sagepub.com/doi/full/10.1177/1060028020928052
Wild Sambucus nigra L. from north-east edge of the species range: A valuable germplasm with inhibitory capacity against SARS-CoV2 S-protein RBD and hACE2 binding in vitro https://www.sciencedirect.com/science/article/abs/pii/S0926669021002028
Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-021-03283-5
Seven recommendations to rescue the patients and reduce the mortality from COVID-19 infection: An immunological point of view https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252097/

Immune support

Elderberry (Sambucus nigra L.) Fruit Extract Alleviates Oxidative Stress, Insulin Resistance, and Inflammation in Hypertrophied 3T3-L1 Adipocytes and Activated RAW 264.7 Macrophages https://www.mdpi.com/2304-8158/8/8/326
Effects of Sambucus nigra and Aronia melanocarpa extracts on immune system disorders within diabetes mellitus https://www.tandfonline.com/doi/full/10.3109/13880209.2014.931441
Concentration of Bioactive Compounds from Elderberry (Sambucus nigra L.) Juice by Nanofiltration Membranes https://link.springer.com/article/10.1007/s11130-018-0686-x

Respiratory Support

Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials https://pubmed.ncbi.nlm.nih.gov/30670267/
Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial https://www.mdpi.com/2072-6643/8/4/182/htm
The effects of Sambucus nigra berry on acute respiratory viral infections: A rapid review of clinical studies https://www.sciencedirect.com/science/article/abs/pii/S2212958820301543
Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses https://link.springer.com/article/10.1186/1472-6882-11-16